Description

3-[(Chlorocarbonyl)Thio]Propanoic Acid Methyl Ester is a versatile sulfur-containing organic acid chloride ester, serving as a critical bifunctional building block in advanced chemical synthesis. Its unique structure, featuring both a reactive acid chloride and a thioester group, makes it an invaluable intermediate for introducing sulfur linkages and carbonyl functionalities. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty polymer industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the production of active pharmaceutical ingredients (APIs), particularly those containing thioester or β-thiopropionate moieties.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and plant growth regulators where the thioester linkage is essential for bioactivity.
• Polymer Modification: Acts as a coupling agent or crosslinker in the synthesis of specialty polymers, including thiourethanes and polymers with pendent reactive groups.
• Peptide Mimetics & Conjugation: Employed in the synthesis of peptide analogs and for bioconjugation strategies, leveraging the reactivity of the acid chloride group.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing sulfur-containing ligands used in coordination chemistry and catalysis.
• Chemical Research: A valuable reagent in organic methodology development for studying new thioesterification and acyl transfer reactions.

Basic Information

Item	Detail
Product Name	3-[(Chlorocarbonyl)Thio]Propanoic Acid Methyl Ester
CAS No.	71850-76-5
Molecular Formula	C5H7ClO3S
Molecular Weight	182.62 g/mol
Synonyms	Methyl 3-[(Chlorocarbonyl)thio]propanoate; 3-(Chlorocarbonylthio)propionic Acid Methyl Ester; Methyl β-(Chlorocarbonylthio)propionate; 3-(Methoxycarbonyl)propanethioic Chloride; Propanethioic Acid, 3-(Methoxycarbonyl)-, Chloride; Thiocarbonic Acid, O-Methyl Ester, Chloride, S-Ester with 3-Mercaptopropionic Acid
EINECS	Contact for details

Quality Control

Our 3-[(Chlorocarbonyl)Thio]Propanoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.