Description

Calcium L-Leucinate is a high-purity, organically-bound calcium salt of the essential amino acid L-Leucine. This compound is valued for its enhanced bioavailability and stability, offering a superior source of bioavailable calcium and leucine in specialized formulations. It is primarily utilized by manufacturers in the pharmaceutical, nutraceutical, and high-end food supplement industries seeking advanced mineral-amino acid chelates for bone health, sports nutrition, and clinical nutrition products.

Application

• Pharmaceutical Formulations: Used as an active pharmaceutical ingredient (API) or excipient in solid dosage forms like tablets and capsules designed for calcium supplementation and bone health management.
• Nutraceuticals & Dietary Supplements: A key component in high-performance supplements targeting muscle protein synthesis, recovery, and bone density support due to the synergistic action of calcium and L-Leucine.
• Clinical Nutrition: Incorporated into medical nutrition products, such as enteral feeds and specialized formulas, for patients with increased nutritional demands or malabsorption issues.
• Sports Nutrition: Found in premium powders, capsules, and ready-to-drink formulations aimed at athletes for enhanced mineral delivery, muscle recovery, and anabolic support.
• Food Fortification: Employed as a mineral fortificant in functional foods and beverages where a highly bioavailable and organoleptically neutral calcium source is required.
• Cosmetic & Personal Care: Investigated for use in topical formulations for skin and hair care, leveraging the role of calcium in skin barrier function and cellular signaling.

Basic Information

Product Name	Calcium L-Leucinate
CAS No.	71720-29-1
Molecular Formula	C12H22CaN2O4
Molecular Weight	298.40 g/mol
Synonyms	L-Leucine, calcium salt; Calcium leucinate; Calcium bis(2-amino-4-methylpentanoate); Calcium L-2-Amino-4-methylvalerate; Calcium (S)-2-Amino-4-methylpentanoate; Leucine calcium salt; (S)-2-Amino-4-methylpentanoic acid calcium salt
EINECS	Contact for details

Quality Control

Our Calcium L-Leucinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical and nutraceutical applications. We provide comprehensive Certificates of Analysis (COA) that detail specifications for identity, purity, and related substances. Our quality commitment aligns with cGMP principles, and we can support documentation for regulatory submissions including DMFs as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture from the air, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation [α]20/D	+14.5° to +16.5° (c=1 in H2O)
pH (5% Solution)	6.0 - 8.0
Loss on Drying	≤ 1.0%
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition (Sulfated Ash)	20.0% - 23.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Microbiological Control	Total Plate Count ≤ 1000 cfu/g; Yeast & Mold ≤ 100 cfu/g; Absence of E. coli, Salmonella

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.