Description

1,1-Bis(Trimethylsilyl)-3-(p-Fluorophenyl)-2-Thiourea is a specialized organosilicon thiourea derivative, a key building block in advanced organic synthesis. Its value lies in its dual functionality, offering both silyl-protecting group capabilities and a reactive thiourea moiety for constructing complex heterocycles and pharmaceutical intermediates. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the p-fluorophenyl group can enhance biological activity and metabolic stability.
• Heterocyclic Chemistry: A versatile reagent for constructing sulfur and nitrogen-containing heterocycles, such as thiazoles and guanidines, which are common scaffolds in medicinal chemistry.
• Organosilicon Chemistry: Functions as a silylating agent and a source of the trimethylsilyl (TMS) group for protecting alcohols, amines, and other sensitive functional groups during multi-step syntheses.
• Material Science Research: Investigated as a monomer or additive for creating novel polymers and advanced materials with specific thermal or electronic properties.
• Catalyst Ligand Development: The thiourea moiety can act as a ligand for metal complexes used in asymmetric catalysis and other transition metal-catalyzed reactions.

Basic Information

Product Name	1,1-Bis(Trimethylsilyl)-3-(p-Fluorophenyl)-2-Thiourea
CAS No.	71457-03-9
Molecular Formula	C13H23FN2SSi2
Molecular Weight	314.57 g/mol
Synonyms	N,N-Bis(trimethylsilyl)-N'-(4-fluorophenyl)thiourea; 1,1-Bis(trimethylsilyl)-3-(4-fluorophenyl)thiourea; 4-Fluoro-N,N-bis(trimethylsilyl)thiocarbanilide; p-Fluorophenyl-1,1-bis(trimethylsilyl)thiourea; BTS-FPTU; TMS-Thiourea Derivative; (4-Fluorophenyl)thiourea, 1,1-bis(trimethylsilyl)-; Thiourea, N,N-bis(trimethylsilyl)-N'-(p-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our 1,1-Bis(Trimethylsilyl)-3-(p-Fluorophenyl)-2-Thiourea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.