Description

2-Bromo-3,3,3-trifluoropropanoic acid is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromine and a trifluoromethyl group, makes it a critical intermediate for introducing fluorine-containing motifs into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the trifluoromethyl group can dramatically alter a compound's metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly those requiring trifluoromethylated or α-branched carboxylic acid derivatives to modulate potency and ADMET properties.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or modifier for creating specialty polymers and coatings with unique surface properties, chemical resistance, or optical characteristics.
• Ligand and Catalyst Development: Employed in the preparation of chiral auxiliaries, ligands for asymmetric catalysis, and other sophisticated organic frameworks in academic and industrial research.
• Fluorine Chemistry Research: An essential reagent for studying nucleophilic substitution and decarboxylation reactions involving fluorinated compounds, enabling the exploration of new synthetic methodologies.

Basic Information

Product Name	2-Bromo-3,3,3-trifluoropropanoic acid
CAS No.	71026-98-7
Molecular Formula	C3H2BrF3O2
Molecular Weight	210.95 g/mol
Synonyms	2-Bromo-3,3,3-trifluoropropionic Acid; α-Bromo-β,β,β-trifluoropropionic Acid; 3,3,3-Trifluoro-2-bromopropanoic Acid; 2-Bromo-3,3,3-trifluoropropanoate; TFBA-Br; Bromotrifluoropropanoic Acid
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,3,3-trifluoropropanoic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.