Description

Rhein 8-B-D-Glucuronide is a specific glucuronide conjugate of the bioactive anthraquinone, Rhein. This compound is of significant interest for its role as a primary metabolite, making it a critical reference standard and analytical tool in pharmacokinetic and metabolic studies. It is essential for researchers and manufacturers in the pharmaceutical and nutraceutical sectors who require high-purity biochemicals for method development, quality control, and bioactivity research.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantification of Rhein and its metabolites in drug formulations and biological matrices via HPLC or LC-MS.
• Metabolite Research: Critical for studying the absorption, distribution, metabolism, and excretion (ADME) profiles of Rhein-based drugs and herbal extracts.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate the biological activity, toxicity, and mechanism of action of glucuronidated anthraquinones.
• Herbal Medicine Analysis: Serves as a key marker compound for the quality control and standardization of traditional Chinese medicines containing Rheum species (e.g., rhubarb).
• Enzyme Activity Assays: Used as a substrate or product in assays for enzymes like β-glucuronidase to study enzyme kinetics and inhibition.

Basic Information

Product Name	Rhein 8-B-D-Glucuronide
CAS No.	70793-10-1
Molecular Formula	C21H18O12
Molecular Weight	462.36 g/mol
Synonyms	Rhein 8-O-β-D-Glucuronide; Rhein-8-glucuronide; 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid 8-(β-D-glucopyranuronosyl) ester; 8-Glucuronyl Rhein; Cassialoin 8-Glucuronide (related); Emodin-8-O-β-D-glucuronide (structural analog); Aloe-emodin-8-glucuronide (structural analog)
EINECS	Contact for details

Quality Control

Our Rhein 8-B-D-Glucuronide is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) specifying batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage, consider keeping the product desiccated at -20°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.