Description

(2R,3S)-2-Hydroxy-3-Methylpentanoic Acid is a high-purity chiral building block essential for the synthesis of complex pharmaceuticals and fine chemicals. This compound matters because its defined stereochemistry is critical for creating molecules with specific biological activity, ensuring efficacy and safety in final products. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active pharmaceutical ingredients (APIs), chiral catalysts, and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and antibiotic drugs.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides to enhance efficacy and reduce environmental impact.
• Fine Chemical Production: Serves as a versatile building block for creating complex natural products, flavors, and fragrances.
• Catalyst Ligand Precursor: Employed in the development of chiral ligands for asymmetric catalysis in organic synthesis.
• Biochemical Research: Utilized as a standard or reagent in enzymatic studies and metabolic pathway research.
• Academic & Industrial R&D: A valuable compound for methodological development in synthetic organic chemistry and process optimization.

Basic Information

Product Name	(2R,3S)-2-Hydroxy-3-Methylpentanoic Acid
CAS No.	70748-47-9
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	(2R,3S)-3-Methyl-2-hydroxypentanoic Acid; D-three-3-Methyl-2-hydroxypentanoic Acid; (2R,3S)-2-Hydroxy-3-methylvaleric Acid; (2R,3S)-3-Methyl-2-hydroxyvaleric Acid; (2R,3S)-HMVA; 2-Hydroxy-3-methylpentanoic Acid (specified stereoisomer); L-Allo-isoleucic Acid (related stereoisomer); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our (2R,3S)-2-Hydroxy-3-Methylpentanoic Acid is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for research and cGMP manufacturing. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.