Description

1-(p-Tolylsulfonyl)Azetidine is a versatile sulfonamide-protected azetidine building block, essential for advanced organic synthesis. Its core value lies in providing a protected, reactive nitrogen heterocycle that enables the construction of complex molecular architectures with high precision. This compound is critically needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon in the development of new drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the azetidine ring contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of novel polymers and functional materials with specific thermal or mechanical properties.
• Chemical Biology Probes: Utilized to build molecular tools for studying enzyme function and cellular pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental building block supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	1-(p-Tolylsulfonyl)Azetidine
CAS No.	7730-45-2
Molecular Formula	C10H13NO2S
Molecular Weight	211.28 g/mol
Synonyms	1-Tosylazetidine; N-(p-Toluenesulfonyl)azetidine; Azetidine, 1-[(4-methylphenyl)sulfonyl]-; 1-(4-Methylphenylsulfonyl)azetidine; 1-(Tosyl)azetidine; 1-(p-Toluenesulfonyl)azetidine; N-Tosylazetidine; 4-Methyl-N-(azetidin-1-yl)benzenesulfonamide
EINECS	Contact for details

Quality Control

Our 1-(p-Tolylsulfonyl)Azetidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete batch data are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.