Description

5'-o-(4-Methylphenylsulphonyl)Thymidine is a key nucleoside derivative and a vital chemical intermediate in organic synthesis. This compound is particularly valued for its role as a protected building block in the synthesis of oligonucleotides and modified nucleic acids, enabling precise control over molecular structure. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing novel therapeutics, diagnostic probes, and advanced research tools.

Application

• Oligonucleotide Synthesis: Serves as a crucial phosphoramidite precursor or protected monomer for solid-phase synthesis of DNA and RNA sequences.
• Antiviral & Anticancer Prodrug Development: Used as an intermediate in the research and synthesis of nucleoside analog prodrugs.
• Bioconjugation & Labeling: Acts as a starting material for creating labeled nucleosides used in diagnostic assays and imaging.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to modify the sugar-phosphate backbone of nucleosides.
• Chemical Biology Tools: Utilized in the development of molecular probes to study enzyme mechanisms and nucleic acid interactions.

Basic Information

Product Name	5'-o-(4-Methylphenylsulphonyl)Thymidine
CAS No.	7253-19-2
Molecular Formula	C17H20N2O7S
Molecular Weight	396.42 g/mol
Synonyms	5'-O-(p-Toluenesulfonyl)thymidine; 5'-O-Tosylthymidine; Thymidine 5'-(4-methylbenzenesulfonate); 1-[(2R,4S,5R)-4-Hydroxy-5-[(4-methylphenyl)sulfonyloxymethyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 5'-O-(4-Methylbenzenesulfonyl)thymidine; TdR-5'-OTs
EINECS	Contact for details

Quality Control

Our 5'-o-(4-Methylphenylsulphonyl)Thymidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.