Description

2-Fluoro-5-(Trimethylstannyl)Pyrimidine is a high-value organotin building block critical for advanced chemical synthesis. This compound matters because it enables precise carbon-carbon bond formation via cross-coupling reactions, a cornerstone of modern pharmaceutical and materials research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated pyrimidine-based compounds.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides that require the pyrimidine scaffold.
• Cross-Coupling Reactions: Serves as a versatile stannyl reagent in Stille coupling reactions for the efficient formation of carbon-carbon bonds.
• Material Science: Precursor for creating functionalized organic electronic materials and liquid crystals.
• Chemical Synthesis: Enables the introduction of the 2-fluoropyrimidine moiety into complex molecules for structure-activity relationship (SAR) studies.
• Lab-Scale to Pilot Plant: Suitable for use from medicinal chemistry discovery through to process chemistry and scale-up activities.

Basic Information

Product Name	2-Fluoro-5-(Trimethylstannyl)Pyrimidine
CAS No.	697300-80-4
Molecular Formula	C9H14FN2Sn
Molecular Weight	287.92 g/mol
Synonyms	5-(Trimethylstannyl)-2-fluoropyrimidine; 2-Fluoro-5-(trimethylstannyl)pyrimidine; Pyrimidine, 2-fluoro-5-(trimethylstannyl)-; 2-Fluoropyrimidine-5-trimethyltin; Trimethyl(5-pyrimidinyl)stannane, 2-fluoro-; Stannane, trimethyl(2-fluoropyrimidin-5-yl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(Trimethylstannyl)Pyrimidine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive coupling reactions and pharmaceutical development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles via validated methods such as NMR, HPLC, and GC.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to strong bases and organic solvents, keep away from incompatible materials. For long-term storage, consider maintaining the product under an inert atmosphere such as argon or nitrogen to ensure optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Tin (Sn) Content	Contact for details
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.