Description

n-(4-Ethynylphenyl)-4-Fluorobenzenesulfonamide is a specialized organic building block featuring a terminal alkyne and a sulfonamide group. This compound is of significant value in medicinal chemistry and materials science for its role as a key intermediate in click chemistry and cross-coupling reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel small-molecule therapeutics, diagnostic agents, and advanced functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of targeted drug candidates, particularly for kinase inhibitors and other biologically active molecules.
• Click Chemistry Reagent: The terminal alkyne moiety enables efficient Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition, CuAAC) for bioconjugation and polymer functionalization.
• Material Science Research: Used in the development of novel organic semiconductors, conductive polymers, and advanced coating materials.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tags for studying biological pathways.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to construct complex molecular architectures.
• High-Throughput Screening Libraries: A valuable scaffold for generating diverse compound libraries in drug discovery programs.

Basic Information

Product Name	n-(4-Ethynylphenyl)-4-Fluorobenzenesulfonamide
CAS No.	691873-32-2
Molecular Formula	C14H10FNO2S
Molecular Weight	275.30 g/mol
Synonyms	4-Fluoro-N-(4-ethynylphenyl)benzenesulfonamide; N-(4-Ethynylphenyl)-4-fluorobenzenesulfonamide; 4-Fluoro-N-(4-ethynylphenyl)benzene-1-sulfonamide; 4-Fluoro-N-(4-ethynylphenyl)benzenesulphonamide; 691873-32-2; 4-Fluoro-N-(4-ethynylphenyl)benzenesulfamide; 4-Fluoro-N-(4-ethynylphenyl)benzenesulfonic acid amide
EINECS	Contact for details

Quality Control

Our n-(4-Ethynylphenyl)-4-Fluorobenzenesulfonamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.