Description

R-2-Methyl Glycidyl p-Nosylate is a high-purity chiral building block and versatile electrophilic reagent. This compound is valued for its role in the stereoselective synthesis of complex molecules, particularly in pharmaceutical research and development. It is essential for chemists in fine chemical, agrochemical, and advanced material sectors who require enantiomerically pure intermediates for constructing active pharmaceutical ingredients (APIs) and other specialty compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure β-blockers, antiviral agents, and other bioactive molecules.
• Asymmetric Synthesis: Used as an electrophilic glycidylating agent in nucleophilic ring-opening reactions to introduce chiral epoxypropyl motifs.
• Agrochemical Research: Serves as a precursor in the development of chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Polymer Modification: Can be used to introduce reactive epoxy and nosylate functional groups into polymer chains for advanced material properties.
• Academic & Process Chemistry: A valuable tool for methodological development in organic synthesis and scale-up process optimization.

Basic Information

Product Name	R-2-Methyl Glycidyl p-Nosylate
CAS No.	683276-64-4
Molecular Formula	C11H13NO6S
Molecular Weight	287.29 g/mol
Synonyms	(R)-2-Methylglycidyl 4-nitrobenzenesulfonate; (R)-1,2-Epoxy-2-methylpropyl 4-nitrobenzenesulfonate; (R)-2-Methyloxiran-2-ylmethyl 4-nitrobenzenesulfonate; p-Nosylate of (R)-2-Methylglycidol; (R)-Methyl Glycidyl Nosylate; (2R)-2-Methyl-2-[(4-nitrophenyl)sulfonyloxymethyl]oxirane; (R)-2-Methylglycidyl 4-Nitrobenzenesulfonate; R-2-Methylglycidyl p-nosylate
EINECS	Contact for details

Quality Control

Our R-2-Methyl Glycidyl p-Nosylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.