Description

(S)-2-(3-tert-Butyl-3-Methylureido)-3,3-Dimethylbutanoic Acid is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. This compound is valued for its role in the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Peptidomimetic Synthesis: Used in the construction of peptide analogs and mimetics due to its ureido and carboxylic acid functional groups.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective chemical reactions to introduce specific three-dimensional configurations.
• Protease Inhibitor Research: Applied in the development of enzyme inhibitors, particularly targeting proteases, where its structure mimics natural substrates.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity chiral compounds.

Basic Information

Product Name	(S)-2-(3-tert-Butyl-3-Methylureido)-3,3-Dimethylbutanoic Acid
CAS No.	681809-31-4
Molecular Formula	C₁₂H₂₄N₂O₃
Molecular Weight	244.33 g/mol
Synonyms	(S)-2-(3-tert-Butyl-3-methylureido)-3,3-dimethylbutanoic acid; (S)-2-[(3-tert-Butyl-3-methylureido)]-3,3-dimethylbutyric acid; (S)-3,3-Dimethyl-2-[(3-methyl-3-(tert-butyl)ureido)]butanoic acid; (S)-N-(tert-Butyl)-N'-methyl-N-(3,3-dimethyl-1-oxobutan-2-yl)urea; (S)-2-(3-tert-Butyl-3-methylureido)-3,3-dimethylbutyric acid; tert-Butyl-methyl-ureido-dimethylbutanoic acid (S-enantiomer); UNII-7F8T2T8Q4S; (S)-Tert-Leucine Ureido Derivative
EINECS	Contact for details

Quality Control

Our (S)-2-(3-tert-Butyl-3-Methylureido)-3,3-Dimethylbutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.