Description

Spiro[Bicyclo[2.2.1]Heptane-2,1-Cyclopropane]-2-Carboxylic Acid, 3,3-Dimethyl- (9Ci) is a specialized spirocyclic carboxylic acid building block valued for its unique three-dimensional, rigid molecular architecture. This compound is critical for advanced research and development in medicinal chemistry, where it serves as a key scaffold to modulate the physicochemical and biological properties of new chemical entities. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers focused on creating novel active pharmaceutical ingredients (APIs), agrochemicals, and high-performance materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in central nervous system (CNS) and antiviral research, where its rigid spirocyclic core can improve metabolic stability and receptor binding.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, where its complex structure can contribute to unique modes of action and environmental persistence profiles.
• Material Science Research: Serves as a precursor or monomer for developing advanced polymers and specialty materials with specific thermal or mechanical properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel chiral ligands or catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized as a core structure in designing molecular probes to study enzyme function and biological pathways.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis, particularly in cyclopropanation and spirocycle formation reactions.

Basic Information

Product Name	Spiro[Bicyclo[2.2.1]Heptane-2,1-Cyclopropane]-2-Carboxylic Acid, 3,3-Dimethyl- (9Ci)
CAS No.	680619-11-8
Molecular Formula	C12H18O2
Molecular Weight	194.27 g/mol
Synonyms	3,3-Dimethylspiro[bicyclo[2.2.1]heptane-2,1'-cyclopropane]-2-carboxylic acid; 2-Norbornaneacetic acid, 3,3-dimethyl-α-methylene-; 3,3-Dimethyl-2-spiro[bicyclo[2.2.1]heptane-2,1'-cyclopropane]carboxylic acid; Spiro[norbornane-2,1'-cyclopropane]-2-carboxylic acid, 3,3-dimethyl derivative; (1'R,2S,3S,4R)-3,3-Dimethylspiro[bicyclo[2.2.1]heptane-2,1'-cyclopropane]-2-carboxylic acid (stereoisomer); Bicyclo[2.2.1]heptane-2-carboxylic acid, 3,3-dimethyl-, spiro compound with cyclopropane; CAS 680619-11-8
EINECS	Contact for details

Quality Control

Our production of Spiro[Bicyclo[2.2.1]Heptane-2,1-Cyclopropane]-2-Carboxylic Acid, 3,3-Dimethyl- (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.