Description

(R)-6,8-Difluorochroman-3-Amine(Wxg00653) is a chiral, fluorinated chroman derivative of significant interest in advanced organic synthesis. This compound serves as a crucial pharmaceutical intermediate and building block for the development of novel active molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries, where its specific stereochemistry and fluorine substitution pattern are leveraged to modulate biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the difluorochroman scaffold can enhance efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in asymmetric synthesis as a precursor for chiral ligands or organocatalysts.
• Chemical Biology Research: Serves as a probe or building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and advanced organic materials.

Basic Information

Product Name	(R)-6,8-Difluorochroman-3-Amine(Wxg00653)
CAS No.	677773-54-5
Molecular Formula	C9H9F2NO
Molecular Weight	185.17 g/mol
Synonyms	(3R)-6,8-Difluoro-3,4-dihydro-2H-1-benzopyran-3-amine; (R)-6,8-Difluoro-3,4-dihydro-2H-chromen-3-amine; (R)-6,8-Difluoro-3-aminochroman; Wxg00653; (R)-3-Amino-6,8-difluorochroman; 6,8-Difluorochroman-3-amine, (R)-; (R)-6,8-Difluoro-2,3-dihydro-4H-chromen-3-amine
EINECS	Contact for details

Quality Control

Our (R)-6,8-Difluorochroman-3-Amine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral HPLC for enantiomeric excess, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) documenting identity, purity, and specific impurities are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.