Description

2H-Pyran-2-One, 6-(2-Aminoethyl)Tetrahydro-4-Hydroxy-, (4R,6R)- (9Ci) is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced organic synthesis. This compound matters because its specific (4R,6R) configuration and functional groups make it a critical building block for the production of complex, biologically active molecules. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents and fine chemicals, where precise molecular architecture is paramount for efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly for cardiovascular and metabolic drugs.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in catalytic asymmetric reactions to induce desired stereochemistry in target molecules.
• Bioconjugate Chemistry: The aminoethyl side chain enables its use in linking pharmacophores or creating targeted drug delivery systems.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in drug discovery and lead optimization programs.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring high enantiomeric purity and specific structural motifs.

Basic Information

Product Name	2H-Pyran-2-One, 6-(2-Aminoethyl)Tetrahydro-4-Hydroxy-, (4R,6R)- (9Ci)
CAS No.	676260-70-1
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	(4R,6R)-6-(2-Aminoethyl)tetrahydro-4-hydroxy-2H-pyran-2-one; (4R,6R)-6-(2-Aminoethyl)-4-hydroxytetrahydro-2H-pyran-2-one; 6-(2-Aminoethyl)tetrahydro-4-hydroxy-2H-pyran-2-one, (4R,6R)-; Atorvastatin Lactone Intermediate; Chiral Dihydroxy Acid Lactone Derivative; (4R-cis)-6-[2-Aminoethyl]tetrahydro-4-hydroxy-2H-pyran-2-one; Tetrahydro-4-hydroxy-6-(2-aminoethyl)-2H-pyran-2-one, (4R,6R)-
EINECS	Contact for details

Quality Control

Our 2H-Pyran-2-One, 6-(2-Aminoethyl)Tetrahydro-4-Hydroxy-, (4R,6R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (4R,6R)-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.