Description

(1R,2R)-[N,N′-Bis(2′,3′-Dihydroxybenzylidene)]-1,2-Diaminocyclohexane is a high-purity, chiral salen-type ligand with the CAS registry number 674285-08-6. This compound is valued for its ability to form stable complexes with various metal ions, making it a critical component in advanced catalytic systems and materials science research. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, fine chemical, and specialty materials sectors for applications requiring precise stereochemical control.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand for enantioselective synthesis, including epoxidation, cyclopropanation, and Diels-Alder reactions.
• Pharmaceutical Intermediates: Used in the research and development of chiral active pharmaceutical ingredients (APIs) where high enantiomeric purity is required.
• Material Science: Employed in the synthesis of metal-organic frameworks (MOFs) and functional polymers with specific optical or catalytic properties.
• Analytical Chemistry: Functions as a chiral selector or complexing agent in chromatography and sensor development for enantiomer separation.
• Coordination Chemistry Research: A key reagent for studying the properties and reactivities of transition metal complexes.
• Fine Chemical Production: Facilitates the manufacture of high-value, optically pure flavors, fragrances, and agrochemicals.

Basic Information

Product Name	(1R,2R)-[N,N′-Bis(2′,3′-Dihydroxybenzylidene)]-1,2-Diaminocyclohexane
CAS No.	674285-08-6
Molecular Formula	C20H22N2O4
Molecular Weight	354.40 g/mol
Synonyms	(1R,2R)-(-)-1,2-Bis(2,3-dihydroxybenzylideneamino)cyclohexane; (1R,2R)-N,N'-Bis(2,3-dihydroxybenzylidene)-1,2-diaminocyclohexane; (R,R)-Jacobsen's Ligand (dihydroxy variant); (1R,2R)-1,2-Diaminocyclohexane-N,N'-bis(2,3-dihydroxybenzaldehyde); (R,R)-H4salen (dihydroxy); Chiral Salen Ligand; (R,R)-Dihydroxysalen; (1R,2R)-Cyclohexanediamine, N,N'-bis(2,3-dihydroxybenzylidene)-
EINECS	Contact for details

Quality Control

Our (1R,2R)-[N,N′-Bis(2′,3′-Dihydroxybenzylidene)]-1,2-Diaminocyclohexane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) documenting identity, purity (typically >97%), and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when possible to prevent oxidation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.