Description

3-Bromo-2-Thienylzinc Bromide is a highly reactive organozinc reagent, specifically a thienylzinc halide, widely used in modern synthetic chemistry. Its core value lies in enabling efficient, selective cross-coupling reactions, such as Negishi coupling, to construct complex heterocyclic and pharmaceutical intermediates. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing the 3-bromo-2-thienyl moiety into target molecules via cross-coupling reactions like Negishi, Suzuki-Miyaura, and Stille couplings.
• Agrochemical Research & Development: Used in the synthesis of novel active ingredients containing thiophene rings, which are common in herbicides and fungicides.
• Material Science & Organic Electronics: Serves as a precursor for constructing π-conjugated systems and heterocyclic cores in organic semiconductors, OLEDs, and conductive polymers.
• Negishi Coupling Reactions: Functions as an efficient organozinc reagent for carbon-carbon bond formation with a variety of electrophiles, including aryl, vinyl, and alkynyl halides.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and metal-organic complexes for catalytic applications.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CROs/CMOs producing bespoke organic compounds for client projects.

Basic Information

Product Name	3-Bromo-2-Thienylzinc Bromide
CAS No.	672325-70-1
Molecular Formula	C4H2Br2SZn
Molecular Weight	304.32 g/mol
Synonyms	2-Thienylzinc bromide, 3-bromo-; Zinc, bromo(3-bromo-2-thienyl)-; 3-Bromo-2-thienylzinc bromide solution; (3-Bromothiophen-2-yl)zinc bromide; Bromo(3-bromo-2-thienyl)zinc; 3-Bromo-2-thienylzinc bromide (0.5M in THF); 3-Bromothiophene-2-zinc bromide
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-2-Thienylzinc Bromide is manufactured and tested under strict quality protocols to ensure consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay/concentration, solvent content, and impurity profile. Our quality system is designed to support cGMP and ISO standards for pharmaceutical and fine chemical production, ensuring traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For solutions, store at 2-8°C. Keep away from heat, sparks, open flames, and strong oxidizing agents. Use only in a well-ventilated fume hood.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to pale yellow solution
Concentration (Typical)	0.5 M in Tetrahydrofuran (THF)
Assay (Titration)	≥ 95%
Identification (NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.