Description

Thp-Peg8-Tos CAS NO 669556-37-0 is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring a tetrahydropyranyl (THP) protecting group and a tosylate (Tos) reactive terminus. This compound is a critical building block in the synthesis of complex molecules, enabling precise conjugation and controlled release strategies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing novel therapeutics, drug delivery systems, and functional polymers.

Application

• Pharmaceutical Linker Chemistry: Serves as a versatile spacer and linker for the controlled attachment of active pharmaceutical ingredients (APIs) to carriers, antibodies, or targeting moieties.
• PEGylation Reagent: Used to introduce polyethylene glycol chains onto drug molecules or surfaces to improve solubility, prolong circulation time, and reduce immunogenicity.
• Prodrug Synthesis: Facilitates the creation of prodrugs where the THP group acts as a cleavable protecting group for alcohols or other functional groups, allowing for targeted activation.
• Polymer Functionalization: A key intermediate for modifying polymer backbones to introduce specific reactive sites for further chemical modification or cross-linking.
• Bioconjugation: Enables the stable and specific coupling of biomolecules (e.g., peptides, proteins, oligonucleotides) for diagnostic and therapeutic applications.
• Material Science: Employed in the surface modification of nanoparticles and biomaterials to enhance biocompatibility and introduce specific chemical functionalities.

Basic Information

Product Name	Thp-Peg8-Tos
CAS No.	669556-37-0
Molecular Formula	C34H60O13S
Molecular Weight	708.9 g/mol
Synonyms	2,5,8,11,14,17,20,23-Octaoxapentacosan-25-ol, 24-[[(4-methylphenyl)sulfonyl]oxy]-, 1-(tetrahydro-2H-pyran-2-yl) ether; Tetrahydropyranyl-PEG8-tosylate; THP-PEG8-OTs; THP-(OCH2CH2)8-OTs; 1-(Tetrahydro-2H-pyran-2-yloxy)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-yl 4-methylbenzenesulfonate; Heterobifunctional PEG derivative THP-PEG8-Tos; THP-PEG8-OTs; Tos-PEG8-THP
EINECS	Contact for details

Quality Control

Our Thp-Peg8-Tos is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting research reproducibility and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.