Description

2H-Pyran-6-Carboxylicacid,2-Ethoxy-3,4-Dihydro-4-Methyl-,Ethylester,(2R,4S)-(9Ci) is a high-purity, stereochemically defined chiral intermediate of significant value in advanced organic synthesis. Its precise molecular architecture makes it a critical building block for the development of complex, biologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals, where stereochemical control is paramount for efficacy and safety.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in therapeutic areas requiring high stereoselectivity.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecular frameworks.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes during drug discovery.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, agrochemicals, and other high-value products where the specific (2R,4S) configuration is required.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and for teaching advanced synthetic techniques.

Basic Information

Item	Details
Product Name	2H-Pyran-6-Carboxylicacid,2-Ethoxy-3,4-Dihydro-4-Methyl-,Ethylester,(2R,4S)-(9Ci)
CAS No.	667894-37-3
Molecular Formula	C11H18O4
Molecular Weight	214.26 g/mol
Synonyms	(2R,4S)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran-6-carboxylic acid ethyl ester; Ethyl (2R,4S)-2-ethoxy-4-methyl-3,4-dihydro-2H-pyran-6-carboxylate; (2R,4S)-Ethyl 2-ethoxy-4-methyl-3,4-dihydro-2H-pyran-6-carboxylate; 2H-Pyran-6-carboxylic acid, 2-ethoxy-3,4-dihydro-4-methyl-, ethyl ester, (2R,4S)-; SCHEMBL2488306; ACH-00002927
EINECS	Contact for details

Quality Control

Every batch of this chiral intermediate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and stereochemical integrity of the product meet the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, typically including results from chiral HPLC, NMR, and mass spectrometry. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (for (2R,4S) isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.