Description

2H-Pyran-2-One, 3-(2-Chloro-1-Hydroxypropyl)-5,6-Dihydro-5-Hydroxy-6-Methyl-, (5R,6S)-Rel-(+)- (9Ci) is a high-purity, stereochemically defined chiral intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a sophisticated building block in the creation of complex, biologically active molecules, offering precise control over stereochemistry. It is primarily needed by research institutions and pharmaceutical development teams focused on synthesizing novel therapeutic agents, agrochemicals, and specialty fine chemicals where structural specificity is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in antibiotic and antiviral drug discovery.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where specific enantiomeric activity is required.
• Academic & Industrial Research: Serves as a valuable reagent in methodological studies for asymmetric synthesis and the development of new catalytic processes.
• Fine Chemical Production: Employed in the manufacture of complex fragrance compounds, flavors, and other high-value specialty chemicals.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	2H-Pyran-2-One, 3-(2-Chloro-1-Hydroxypropyl)-5,6-Dihydro-5-Hydroxy-6-Methyl-, (5R,6S)-Rel-(+)- (9Ci)
CAS No.	664354-71-6
Molecular Formula	C9H13ClO4
Molecular Weight	220.65 g/mol
Synonyms	(5R,6S)-rel-3-(2-Chloro-1-hydroxypropyl)-5,6-dihydro-5-hydroxy-6-methyl-2H-pyran-2-one; (+)-rel-(5R,6S)-3-(2-Chloro-1-hydroxypropyl)-5,6-dihydro-5-hydroxy-6-methyl-2H-pyran-2-one; 3-(2-Chloro-1-hydroxypropyl)-5,6-dihydro-5-hydroxy-6-methyl-2H-pyran-2-one, (5R,6S)-rel-(+)-; CAS 664354-71-6; Chiral Dihydroxypyranone Derivative; Chlorohydroxypropyl Dihydroxypyranone
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, chiral chromatography, NMR, and mass spectrometry to confirm identity, enantiomeric excess, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and cGMP-compliant projects with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.