Description

2,3,4,5,6-Pentafluorophenyl 4-Methoxybenzenesulfonate is a specialized organofluorine sulfonate ester, a high-value intermediate in advanced synthetic chemistry. This compound matters for its role as a versatile electrophilic reagent, enabling the efficient introduction of the pentafluorophenylsulfonyl (Pfp) group, a key moiety in the synthesis of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing sulfonamides, sulfonate esters, and other functionalized architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing sulfonamide or sulfonate ester functionalities.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the pentafluorophenyl group enhances biological activity and stability.
• Peptide Chemistry & Bioconjugation: Serves as an activating agent for sulfonylation reactions in peptide synthesis and for creating stable bioconjugates in probe and drug delivery system development.
• Polymer & Materials Science: Employed as a monomer or cross-linking agent in the production of specialty polymers, including fluorinated polymers with unique surface properties and thermal stability.
• Ligand & Catalyst Development: Utilized in the preparation of specialized ligands and organocatalysts for asymmetric synthesis and transition metal catalysis.
• Chemical Biology Probes: Acts as a reagent for labeling biomolecules (proteins, nucleic acids) with fluorinated tags for imaging and mechanistic studies.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 4-Methoxybenzenesulfonate
CAS No.	663175-94-8
Molecular Formula	C₁₃H₇F₅O₄S
Molecular Weight	354.25 g/mol
Synonyms	4-Methoxybenzenesulfonic Acid 2,3,4,5,6-Pentafluorophenyl Ester; Pentafluorophenyl 4-Methoxybenzenesulfonate; Pentafluorophenyl Tosylate Analog; Pfp 4-Methoxybenzenesulfonate; 4-Methoxybenzenesulfonyl Pentafluorophenyl Ester; 4-Methoxyphenylsulfonyl Pentafluorophenyl Ester; Pentafluorophenyl 4-Methoxyphenylsulfonate
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenyl 4-Methoxybenzenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.