Description

2,3,4,5,6-Pentafluorophenyl 3-Nitrobenzenesulphonate is a specialized fluorinated sulfonate ester, a high-value building block in advanced organic synthesis. Its core value lies in its role as a potent and selective electrophilic reagent for introducing the pentafluorophenylsulfonyl (Pfp) group, a versatile protecting and activating moiety. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide derivatives and prodrugs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require fluorinated aromatic components.
• Peptide Chemistry: Serves as a coupling agent or protecting group reagent in solid-phase peptide synthesis (SPPS).
• Material Science: Building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials with unique fluorinated properties.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and labeling reagents for proteomics research.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed cross-coupling reactions to form biaryl systems.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 3-Nitrobenzenesulphonate
CAS No.	663175-93-7
Molecular Formula	C12H4F5NO5S
Molecular Weight	369.22 g/mol
Synonyms	Pentafluorophenyl 3-nitrobenzenesulfonate; 3-Nitrobenzenesulfonic acid pentafluorophenyl ester; PFP-3-Nitrobenzenesulfonate; NSC 405124; 2,3,4,5,6-Pentafluorophenyl 3-nitrobenzene-1-sulfonate; Pentafluorophenyl 3-nitrobenzene-1-sulfonate; 3-Nitrobenzenesulfonyl pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenyl 3-Nitrobenzenesulphonate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.