Description

(3-Amino-4-Methyl-Phenyl)-Carbamic Acid tert-Butyl Ester is a high-purity, protected aniline derivative serving as a critical building block in advanced organic synthesis. Its value lies in the tert-butyloxycarbonyl (Boc) protecting group, which safeguards the amine functionality during multi-step reactions, enabling the precise construction of complex molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, particularly for APIs and fine chemicals requiring controlled amine reactivity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for compounds containing substituted aniline moieties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the protected amine group is crucial for selective reactions.
• Peptide Mimetics & Drug Discovery: Serves as a building block for creating non-peptide scaffolds and small molecule libraries in medicinal chemistry programs.
• Dye & Pigment Precursor: Employed in the synthesis of specialized azo dyes and high-performance pigments requiring specific amino-methyl-phenyl structures.
• Material Science Research: Acts as a monomer or functionalization agent in the development of advanced polymers and functional organic materials.
• Cross-Coupling Reactions: A suitable substrate for Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions to form complex biaryl amines.

Basic Information

Product Name	(3-Amino-4-Methyl-Phenyl)-Carbamic Acid tert-Butyl Ester
CAS No.	660838-05-1
Molecular Formula	C12H18N2O2
Molecular Weight	222.28 g/mol
Synonyms	N-Boc-3-Amino-4-methylaniline; tert-Butyl (3-amino-4-methylphenyl)carbamate; 3-Amino-4-methylphenylcarbamic Acid tert-Butyl Ester; BOC-3-Amino-4-methylaniline; 1-tert-Butoxycarbonylamino-2-methyl-5-aminobenzene; N-(tert-Butoxycarbonyl)-3-amino-p-toluidine; 4-Methyl-3-aminophenyl Carbamic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our (3-Amino-4-Methyl-Phenyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance in cGMP and ISO 9001 environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if frequent access is required. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.