Description

[5-(Trifluoromethyl)Pyridin-2-Yl]Tributylstannane is a high-value organotin reagent, specifically a pyridyl-substituted tributylstannane, essential for advanced cross-coupling reactions in synthetic chemistry. Its core value lies in enabling the efficient, selective introduction of the 5-(trifluoromethyl)pyridin-2-yl moiety into complex molecular architectures, a key step in developing novel active compounds. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing next-generation molecules with tailored properties.

Application

• Pharmaceutical Intermediate Synthesis: A crucial building block for Stille cross-coupling reactions to incorporate the trifluoromethylpyridine group into potential drug candidates, particularly in medicinal chemistry for CNS and oncology targets.
• Agrochemical Active Ingredient Development: Used to synthesize novel herbicides, fungicides, and insecticides where the trifluoromethylpyridine unit enhances biological activity and environmental stability.
• Ligand and Catalyst Precursor: Serves as a starting material for creating specialized pyridine-based ligands used in homogeneous catalysis and material science applications.
• Functional Material Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs or semiconductors, where the stannane group facilitates precise molecular assembly.
• Custom Chemical and Contract Research: A key reagent for custom synthesis houses and CROs (Contract Research Organizations) working on client-specific molecular scaffolds requiring this unique heterocyclic fragment.
• Academic Research: Used in university and institutional labs for methodological development in organometallic chemistry and the exploration of new coupling methodologies.

Basic Information

Product Name	[5-(Trifluoromethyl)Pyridin-2-Yl]Tributylstannane
CAS No.	659722-71-1
Molecular Formula	C18H30F3NSn
Molecular Weight	428.14 g/mol
Synonyms	Tributyl[5-(trifluoromethyl)pyridin-2-yl]stannane; 2-Tributylstannyl-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-(tributylstannyl)pyridine; 2-(Tributylstannyl)-5-(trifluoromethyl)pyridine; (5-Trifluoromethyl-2-pyridyl)tributyltin; Tributyl(5-trifluoromethyl-2-pyridyl)tin; Stannane, tributyl[5-(trifluoromethyl)-2-pyridinyl]-
EINECS	Contact for details

Quality Control

Our [5-(Trifluoromethyl)Pyridin-2-Yl]Tributylstannane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized by NMR (1H, 13C, 19F), HPLC, and other relevant analytical techniques to confirm identity and purity. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases and incompatible materials. Ensure the storage area is well-ventilated.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
1H NMR Purity	≥ 95.0%
Tin (Sn) Content	27.0 - 28.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.