Description

5,7-Bis(Acetyloxy)-3-[4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Phenyl]-4H-1-Benzopyran-4-One is a high-purity, advanced pharmaceutical intermediate featuring a protected phenolic group, which is critical for controlled synthesis in complex organic reactions. This compound is valued for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly in the flavonoid and chromone chemical space. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking reliable, high-quality intermediates for scalable synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those with chromone or flavonoid backbones.
• Organic Synthesis Building Block: Used in research and development for constructing complex molecular architectures, leveraging the silyl-protected phenol for selective reactions.
• Medicinal Chemistry Research: Employed in the discovery and optimization of new chemical entities targeting a range of biological pathways.
• Process Chemistry & Scale-Up: Provides a consistent starting material for process development and pilot-scale manufacturing of advanced intermediates.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.
• Biochemical Research: Potential use in studying enzyme interactions or as a probe due to its specific chromone structure.

Basic Information

Product Name	5,7-Bis(Acetyloxy)-3-[4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Phenyl]-4H-1-Benzopyran-4-One
CAS No.	656229-80-0
Molecular Formula	C25H28O7Si
Molecular Weight	468.57 g/mol
Synonyms	5,7-Diacetoxy-3-[4-[(tert-butyldimethylsilyl)oxy]phenyl]-4H-chromen-4-one; 3-(4-((tert-Butyldimethylsilyl)oxy)phenyl)-5,7-diacetoxy-4H-chromen-4-one; TBDMS-protected 5,7-diacetoxyflavone derivative; 4H-1-Benzopyran-4-one, 5,7-bis(acetyloxy)-3-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-; Flavone derivative, TBDMS ether, 5,7-diacetate
EINECS	Contact for details

Quality Control

Our 5,7-Bis(Acetyloxy)-3-[4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Phenyl]-4H-1-Benzopyran-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.