Description

2-Chloro-N-[2-(trifluoromethoxy)phenyl]acetamide is a specialized halogenated acetamide derivative featuring a trifluoromethoxy substituent, offering unique reactivity and physicochemical properties. This compound is valued as a key synthetic intermediate in advanced organic synthesis, particularly for constructing complex molecules with tailored functionalities. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, where the chloroacetamide and trifluoromethoxy groups can contribute to biological activity and environmental persistence profiles.
• Material Science Precursor: Acts as a monomer or functionalization agent in the creation of specialty polymers and advanced materials with specific surface properties or chemical resistance.
• Chemical Synthesis Reagent: Employed in organic laboratories for nucleophilic substitution reactions, amide bond formations, and as a scaffold for further derivatization in medicinal chemistry programs.
• Fluorine Chemistry Studies: Provides a valuable template for investigating the influence of the trifluoromethoxy group on chemical reactivity and physical properties in comparative studies.

Basic Information

Product Name	2-Chloro-N-[2-(trifluoromethoxy)phenyl]acetamide
CAS No.	656227-27-9
Molecular Formula	C9H7ClF3NO2
Molecular Weight	253.61 g/mol
Synonyms	2-Chloro-N-[2-(trifluoromethoxy)phenyl]acetamide; N-(2-(Trifluoromethoxy)phenyl)-2-chloroacetamide; 2-Chloro-2',2',2'-trifluoroacet-o-anisidide; α-Chloro-2'-(trifluoromethoxy)acetanilide; Acetamide, 2-chloro-N-[2-(trifluoromethoxy)phenyl]-; 656227-27-9; 2-Chloro-N-(2-trifluoromethoxyphenyl)acetamide
EINECS	Contact for details

Quality Control

Our 2-Chloro-N-[2-(trifluoromethoxy)phenyl]acetamide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.