Description

Ethyl 2-Amino-2-(Tetrahydro-2H-Pyran-4-Yl)Acetate is a high-value, non-proteinogenic amino acid ester derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a tetrahydro-2H-pyran-4-yl moiety, makes it an essential intermediate for constructing complex molecules with specific stereochemistry. This compound is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Peptidomimetics Synthesis: Used to incorporate constrained, non-natural amino acid residues into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Catalysis & Ligand Development: Serves as a precursor for chiral ligands and catalysts used in enantioselective synthesis.
• Agrochemical Research: Employed in the development of advanced, stereochemically defined pesticides and herbicides.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.
• Custom Synthesis Building Block: Provided for contract research organizations (CROs) and CDMOs requiring specific, high-purity chiral intermediates.

Basic Information

Product Name	Ethyl 2-Amino-2-(Tetrahydro-2H-Pyran-4-Yl)Acetate
CAS No.	646055-93-8
Molecular Formula	C9H17NO3
Molecular Weight	187.24 g/mol
Synonyms	Ethyl 2-Amino-2-(Tetrahydro-2H-Pyran-4-Yl)Acetate; 2-Amino-2-(Tetrahydro-2H-Pyran-4-Yl)Acetic Acid Ethyl Ester; Ethyl 2-Amino-2-(Oxan-4-yl)Acetate; 4-Piperidineacetic Acid, α-Amino-, Ethyl Ester, Tetrahydro Derivative; (Ethoxycarbonyl)(Tetrahydro-2H-Pyran-4-yl)Methylamine; 646055-93-8; Amino Acid Ester Derivative; THP-Protected Amino Acid Ester.
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-Amino-2-(Tetrahydro-2H-Pyran-4-Yl)Acetate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. We employ advanced analytical techniques, including chiral HPLC and NMR, to verify identity, enantiomeric excess, and impurity profiles. Certificates of Analysis (COA) detailing all critical specifications are provided with each shipment. Our quality systems are designed to support cGMP compliance for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.