Description

4-Chloro-5-Hydroxy-2-(2-Tetrahydropyranyl)Pyridazin-3(2H)-One is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 645405-18-1. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling precise molecular construction. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Serves as a precursor for developing advanced herbicides and pesticides with specific modes of action.
• Chemical Research & Development: Used in academic and industrial R&D labs for exploring new heterocyclic chemistry and creating proprietary compound libraries.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the final chemical structure of APIs requiring the pyridazinone pharmacophore.
• Process Chemistry: Employed in scale-up and optimization studies for efficient and cost-effective manufacturing routes.

Basic Information

Product Name	4-Chloro-5-Hydroxy-2-(2-Tetrahydropyranyl)Pyridazin-3(2H)-One
CAS No.	645405-18-1
Molecular Formula	C9H9ClN2O3
Molecular Weight	228.63 g/mol
Synonyms	4-Chloro-5-hydroxy-2-(tetrahydro-2H-pyran-2-yl)-2,3-dihydropyridazin-3-one; 2H-Pyridazin-3-one, 4-chloro-5-hydroxy-2-(tetrahydro-2H-pyran-2-yl)-; 4-Chloro-5-hydroxy-2-(2-tetrahydropyranyl)-3(2H)-pyridazinone; THP-protected chlorohydroxypyridazinone; Pyridazinone derivative CAS 645405-18-1
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Hydroxy-2-(2-Tetrahydropyranyl)Pyridazin-3(2H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.