Description

1,2-Benzenediol, 5-Chloro-3-Fluoro- is a halogenated dihydroxybenzene derivative, a versatile and high-value organic intermediate. Its unique structure, featuring both chloro and fluoro substituents on the catechol ring, makes it a critical building block for synthesizing advanced molecules with tailored properties. This compound is essential for research and development chemists and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to create novel active ingredients. The product is supplied under stringent quality control to ensure batch-to-batch consistency for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Serves as a core building block for developing new herbicides, fungicides, and insecticides, where the chloro and fluoro groups enhance biological activity and environmental persistence.
• Material Science Research: Used in the development of specialty polymers, ligands for catalysis, and advanced organic electronic materials due to its reactive dihydroxy functionality.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry for exploring new synthetic routes and creating compound libraries.

Basic Information

Product Name	1,2-Benzenediol, 5-Chloro-3-Fluoro-
CAS No.	645405-05-6
Molecular Formula	C6H4ClFO2
Molecular Weight	162.55 g/mol
Synonyms	5-Chloro-3-fluorobenzene-1,2-diol; 5-Chloro-3-fluorocatechol; 3-Fluoro-5-chlorocatechol; 1,2-Dihydroxy-5-chloro-3-fluorobenzene; 5-Chloro-3-fluoro-1,2-benzenediol; 5-Chloro-3-fluoropyrocatechol; 3-Fluoro-5-chloro-1,2-dihydroxybenzene
EINECS	Contact for details

Quality Control

Our 1,2-Benzenediol, 5-Chloro-3-Fluoro- is manufactured under a strict quality management system. Every batch is subjected to comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support compliance with REACH and other global regulatory frameworks, and custom purity grades can be produced to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.