Description

2-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Allyloxy]-Tetrahydro-Pyran is a versatile and highly valuable protected boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for oncology and central nervous system (CNS) therapies.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science & Polymer Chemistry: Used in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Probe Development: Enables the labeling and modification of biomolecules for diagnostic and research applications.
• Cross-Coupling Reactions: A reliable boron source in palladium-catalyzed Suzuki-Miyaura couplings for constructing biaryl and complex aromatic systems.
• Organic Synthesis Research: A fundamental reagent in academic and industrial R&D laboratories for method development and complex molecule construction.

Basic Information

Product Name	2-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Allyloxy]-Tetrahydro-Pyran
CAS No.	642066-70-4
Molecular Formula	C14H25BO4
Molecular Weight	268.16 g/mol
Synonyms	2-(3-((Tetrahydro-2H-pyran-2-yl)oxy)prop-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; THP-Protected Allyl Boronic Acid Pinacol Ester; 2-(3-(Tetrahydro-2H-pyran-2-yloxy)-1-propenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Allyloxy-THP Pinacol Boronate; 3-(Tetrahydro-2H-pyran-2-yloxy)prop-1-en-1-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Allyloxy]-Tetrahydro-Pyran is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.