Description

6-(Trifluoromethyl)-4,5-Dihydropyridazin-3(2H)-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl-substituted dihydropyridazinone scaffold, which is crucial for modulating the biological activity and metabolic stability of target molecules. This compound is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, serving as a key intermediate in medicinal chemistry and crop protection science.

Application

• Pharmaceutical Intermediate: A critical synthon for the research and development of new drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating tool compounds and probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a precursor for specialty polymers and advanced materials requiring fluorine incorporation for specific thermal or chemical resistance properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP for clinical trial materials.

Basic Information

Product Name	6-(Trifluoromethyl)-4,5-Dihydropyridazin-3(2H)-One
CAS No.	628332-15-0
Molecular Formula	C5H5F3N2O
Molecular Weight	166.10 g/mol
Synonyms	6-(Trifluoromethyl)-2,3,4,5-tetrahydropyridazin-3-one; 3(2H)-Pyridazinone, 4,5-dihydro-6-(trifluoromethyl)-; 6-Trifluoromethyl-4,5-dihydro-3(2H)-pyridazinone; 4,5-Dihydro-6-(trifluoromethyl)pyridazin-3(2H)-one; 2,3,4,5-Tetrahydro-6-(trifluoromethyl)pyridazin-3-one; TFMPD; Trifluoromethyl dihydropyridazinone
EINECS	Contact for details

Quality Control

Every batch of 6-(Trifluoromethyl)-4,5-Dihydropyridazin-3(2H)-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the exacting standards required for research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profile as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.