Description

4H-1-Benzopyran-4-One, 5,6,7,8-Tetrahydro-6,7-Dihydroxy-2-(2-Phenylethyl)-, (6S,7R)-Rel-(-)- CAS NO 626236-07-5 is a high-purity, stereochemically defined chroman derivative, a key chiral building block in advanced organic synthesis. Its value lies in the precise (6S,7R)-rel-(-)- configuration, which is critical for imparting specific biological activity and stereoselectivity in final products. This compound is essential for R&D chemists and manufacturers in the pharmaceutical and fine chemical industries developing novel active pharmaceutical ingredients (APIs) and specialty intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug candidates, particularly those targeting neurological or cardiovascular pathways.
• Asymmetric Synthesis: Utilized as a sophisticated building block for constructing molecules with high enantiomeric purity in medicinal chemistry programs.
• Natural Product Synthesis: Acts as a core structural motif for the laboratory synthesis or structural modification of natural products containing chroman or flavan-like scaffolds.
• Biochemical Research: Used as a reference standard or probe in biochemical assays to study enzyme interactions or receptor binding where the specific stereochemistry is a factor.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and high-value performance materials requiring defined stereocenters.

Basic Information

Product Name	4H-1-Benzopyran-4-One, 5,6,7,8-Tetrahydro-6,7-Dihydroxy-2-(2-Phenylethyl)-, (6S,7R)-Rel-(-)-
CAS No.	626236-07-5
Molecular Formula	C17H18O4
Molecular Weight	286.32 g/mol
Synonyms	(-)-6,7-Dihydroxy-2-phenethyl-5,6,7,8-tetrahydrochromen-4-one; (6S,7R)-rel-6,7-Dihydroxy-2-(2-phenylethyl)-5,6,7,8-tetrahydro-4H-chromen-4-one; 5,6,7,8-Tetrahydro-6,7-dihydroxy-2-(2-phenylethyl)-4H-chromen-4-one, (6S,7R)-rel-(-)-; 2-Phenethyl-5,6,7,8-tetrahydro-6,7-dihydroxychromone; rel-(-)-Dihydroxy-phenethyl-tetrahydrochromone
EINECS	Contact for details

Quality Control

Every batch of this chiral intermediate is produced under strict quality management systems. We employ advanced analytical techniques, including Chiral HPLC and NMR, to verify stereochemical purity, chemical identity, and overall assay. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to ensure it meets your precise research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its light-sensitive and easily oxidized nature, long-term storage under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) is recommended to maintain stability and potency. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.