Description

1-[3,5-Bis(Trifluoromethyl)Phenyl]-3-[(1R,2R)-(-)-2-(Dimethylamino)Cyclohexyl]Thiourea (R,R-TUC) is a high-value, chiral thiourea derivative organocatalyst. This compound matters for its role in facilitating highly enantioselective transformations, a critical requirement in modern asymmetric synthesis for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking efficient and selective catalytic pathways.

Application

• Asymmetric Organocatalysis: Employed as a bifunctional hydrogen-bond donor catalyst for enantioselective reactions such as Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: Critical in the R&D and scale-up production of chiral drug candidates and APIs where stereochemical purity is paramount.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Methodology Development: A valuable tool compound for academic and industrial researchers exploring new catalytic asymmetric methodologies.
• Fine Chemical Production: Applied in the synthesis of complex, high-value chiral molecules for flavors, fragrances, and electronic chemicals.
• Ligand for Metal Complexes: Can serve as a precursor or auxiliary ligand in the formation of chiral metal complexes for catalysis.

Basic Information

Product Name	1-[3,5-Bis(Trifluoromethyl)Phenyl]-3-[(1R,2R)-(-)-2-(Dimethylamino)Cyclohexyl]Thiourea (R,R-TUC)
CAS No.	620960-26-1
Molecular Formula	C₁₇H₁₉F₆N₃S
Molecular Weight	427.41 g/mol
Synonyms	(1R,2R)-1-[3,5-Bis(trifluoromethyl)phenyl]-3-[2-(dimethylamino)cyclohexyl]thiourea; (R,R)-TUC; (R,R)-Thiourea Catalyst; (1R,2R)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2-(dimethylamino)cyclohexyl]thiourea; R,R-TUC Organocatalyst; (R,R)-1,3-Bis[3,5-bis(trifluoromethyl)phenyl]thiourea derivative; Chiral Thiourea Catalyst TUC; Takemoto Catalyst Derivative
EINECS	Contact for details

Quality Control

Our R,R-TUC is manufactured under strict quality control protocols to ensure high enantiomeric excess (ee) and chemical purity, critical for reproducible catalytic performance. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity, assay, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements in advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and catalytic activity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.