Description

5-Oxo-6-Trifluoromethanesulfonyloxy-1,2,3,5-Tetrahydroindolizine is a high-value, advanced pharmaceutical intermediate characterized by its unique indolizine core and reactive trifluoromethanesulfonyloxy (triflate) group. This compound is critical for facilitating complex carbon-carbon and carbon-heteroatom bond formations in medicinal chemistry, enabling the synthesis of novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex indolizine-based drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in cross-coupling reactions (e.g., Suzuki, Negishi) to introduce the indolizine moiety into lead compounds for structure-activity relationship (SAR) studies.
• Process Chemistry Development: Serves as a versatile intermediate in scaling up synthetic routes for preclinical and clinical trial material.
• Agrochemical Synthesis: Potential intermediate in the research and development of novel herbicides or fungicides with the indolizine scaffold.
• Material Science Research: Exploration as a precursor for organic electronic materials due to its fused heterocyclic structure.

Basic Information

Product Name	5-Oxo-6-Trifluoromethanesulfonyloxy-1,2,3,5-Tetrahydroindolizine
CAS No.	612065-04-0
Molecular Formula	C9H8F3NO4S
Molecular Weight	283.22 g/mol
Synonyms	6-(Trifluoromethanesulfonyloxy)-1,2,3,5-tetrahydro-5-oxoindolizine; 5-Oxo-6-triflyloxy-1,2,3,5-tetrahydroindolizine; 1,2,3,5-Tetrahydro-5-oxoindolizine-6-yl trifluoromethanesulfonate; 5-Oxo-6-((trifluoromethyl)sulfonyl)oxy)-1,2,3,5-tetrahydroindolizine; Indolizine-6-triflate intermediate
EINECS	Contact for details

Quality Control

Our production of 5-Oxo-6-Trifluoromethanesulfonyloxy-1,2,3,5-Tetrahydroindolizine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is fully characterized and accompanied by a comprehensive Certificate of Analysis (COA). Our quality management system supports the traceability and documentation required for cGMP and ISO environments. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.