Description

L-Proline, 5-Oxo-4-(2-Propenyl)-, (4S)- (9Ci) is a specialized, non-proteinogenic proline derivative featuring a 5-oxo (pyroglutamate) moiety and a 2-propenyl (allyl) substituent. This unique chiral building block is of significant value in advanced organic synthesis and pharmaceutical research, particularly for constructing complex peptide mimetics and bioactive molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for developing novel active ingredients and exploring new synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors and other enzyme-targeted therapeutics.
• Peptidomimetic Research: Used to introduce conformational constraints and novel side-chain functionalities into peptide backbones to enhance stability, bioavailability, and receptor selectivity.
• Agrochemical Development: Serves as a building block for creating new herbicides, fungicides, or plant growth regulators with specific chiral activity.
• Asymmetric Synthesis Catalyst/ Ligand Precursor: The rigid proline scaffold can be modified to create novel organocatalysts or chiral ligands for metal-catalyzed reactions.
• Biochemical Research: Employed in studies of enzyme mechanisms, substrate specificity, and metabolic pathways involving proline or glutamate derivatives.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex natural products, flavors, or fragrances requiring specific chiral centers.

Basic Information

Item	Detail
Product Name	L-Proline, 5-Oxo-4-(2-Propenyl)-, (4S)- (9Ci)
CAS No.	607732-04-7
Molecular Formula	C8H11NO3
Molecular Weight	169.18 g/mol
Synonyms	(4S)-5-Oxo-4-(prop-2-en-1-yl)pyrrolidine-2-carboxylic acid; 4-Allyl-5-oxo-L-proline; L-4-Allyl-5-oxoproline; 5-Oxo-4-(2-propenyl)-L-proline; (S)-4-Allyl-5-oxopyrrolidine-2-carboxylic acid; 4-Allylpyroglutamic acid; Allyl-substituted L-pyroglutamic acid
EINECS	Contact for details

Quality Control

Our L-Proline, 5-Oxo-4-(2-Propenyl)-, (4S)- (9Ci) is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for chiral purity, assay, and specific impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.