Description

(S)-2-((tert-Butoxycarbonyl)Amino)Pentane-1,5-Diyl Dimethanesulfonate is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its core value lies in providing a protected, activated diol derivative that enables the stereoselective construction of complex molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for advanced synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those containing amino alcohol or diamine pharmacophores.
• Peptidomimetic Synthesis: Used to introduce constrained, non-natural amino acid analogs into peptide chains to enhance stability and biological activity.
• Asymmetric Synthesis: Serves as a precursor for chiral ligands, catalysts, or auxiliaries used in enantioselective transformations.
• Prodrug Development: The dimethanesulfonate (dimesylate) groups act as leaving groups, making it valuable for designing prodrugs or conjugates with improved pharmacokinetic properties.
• Chemical Biology Probes: Utilized in the creation of labeled or tagged molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing specialized compounds for client R&D programs.

Basic Information

Product Name	(S)-2-((tert-Butoxycarbonyl)Amino)Pentane-1,5-Diyl Dimethanesulfonate
CAS No.	607376-86-3
Molecular Formula	C13H27NO8S2
Molecular Weight	397.48 g/mol
Synonyms	1,5-Pentanediol, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)-, 1,5-dimethanesulfonate; (2S)-2-[(tert-Butoxycarbonyl)amino]pentane-1,5-diyl dimethanesulfonate; (S)-2-(Boc-Amino)pentane-1,5-diyl dimesylate; Boc-L-2-Aminopentane-1,5-diol dimesylate; (S)-N-Boc-1,5-dimesyloxypentan-2-amine; (S)-1,5-Bis(methanesulfonyloxy)-2-((tert-butoxycarbonyl)amino)pentane
EINECS	Contact for details

Quality Control

Our production of (S)-2-((tert-Butoxycarbonyl)Amino)Pentane-1,5-Diyl Dimethanesulfonate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for advanced synthetic applications. Each lot undergoes comprehensive analytical characterization, including chiral purity verification. Certificates of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profiles are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.