Description

2H-Pyran-2-One, 3-(Difluoroacetyl)Tetrahydro- (9Ci) is a specialized heterocyclic building block featuring a fused pyranone and tetrahydrofuran structure with a difluoroacetyl substituent. This compound matters as a high-value synthetic intermediate, offering unique reactivity for constructing complex molecular architectures in advanced chemical synthesis. Pharmaceutical, agrochemical, and advanced material researchers need it for developing novel active ingredients and functional molecules. Its precise structure enables targeted modifications that are critical for innovation in life sciences and specialty chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, where the difluoroacetyl group can enhance biological activity and environmental profile.
• Fluorinated Building Block: Provides a source of fluorine atoms for medicinal chemistry, leveraging the fluorine effect to improve metabolic stability, bioavailability, and binding affinity of drug candidates.
• Material Science: Acts as a monomer or cross-linking agent in the research of specialty polymers and coatings with tailored thermal or chemical resistance properties.
• Chemical Synthesis: Employed in academic and industrial R&D for constructing complex heterocyclic frameworks common in natural product synthesis and catalyst design.
• Ligand & Catalyst Development: Utilized in the preparation of novel chiral ligands or organocatalysts for asymmetric synthesis applications.

Basic Information

Product Name	2H-Pyran-2-One, 3-(Difluoroacetyl)Tetrahydro- (9Ci)
CAS No.	606491-81-0
Molecular Formula	C7H8F2O3
Molecular Weight	178.14 g/mol
Synonyms	3-(Difluoroacetyl)tetrahydro-2H-pyran-2-one; Tetrahydro-3-(difluoroacetyl)-2H-pyran-2-one; 3-Difluoroacetyltetrahydro-2H-pyran-2-one; 606491-81-0; 2H-Pyran-2-one, 3-(difluoroacetyl)tetrahydro-; 3-(2,2-Difluoroacetyl)tetrahydropyran-2-one
EINECS	Contact for details

Quality Control

Every batch of 2H-Pyran-2-One, 3-(Difluoroacetyl)Tetrahydro- (9Ci) undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality management system is designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), impurity profile, and physical characteristics is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.