Description

Mk-0773 is a potent and selective small molecule inhibitor of the enzyme p38 mitogen-activated protein kinase (MAPK). This compound is a critical research tool for studying cellular signaling pathways related to inflammation, stress response, and apoptosis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and mechanistic biology studies. The product, identified by CAS No. 606101-58-0, is supplied as a high-purity biochemical for investigative use.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of p38 MAPK in various cellular processes and disease models.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in the development of novel anti-inflammatory and anti-cancer therapeutics.
• Cell Signaling Pathway Analysis: Employed in vitro to elucidate the downstream effects of p38 MAPK inhibition on gene expression and protein synthesis.
• Academic Research: A key reagent for university and institutional labs investigating inflammation, cytokine biology, and cellular stress responses.
• Target Validation Studies: Used to confirm the biological and therapeutic relevance of p38 MAPK as a drug target in specific indications.

Basic Information

Product Name	Mk-0773
CAS No.	606101-58-0
Molecular Formula	C₂₀H₂₀N₄O₂S
Molecular Weight	380.46 g/mol
Synonyms	MK-0773; 5-(2-(Phenylamino)pyrimidin-4-yl)thiazol-2-amine; BIRB 796; Doramapimod; p38 MAP Kinase Inhibitor, BIRB 796; 1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; (2S,3S,4R,5S)-2-(4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl)-1,5-anhydro-D-glucitol; BIRB 796 BS
EINECS	Contact for details

Quality Control

Our Mk-0773 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to high standards suitable for research and development use, with specifications typically meeting or exceeding 98% purity by HPLC. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.