Description

tert-Butyl (Cis)-6-(Hydroxymethyl)-Tetrahydro-2H-Pyran-3-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in antiviral and neurological drug development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in process chemistry and the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex antiviral and neurological drugs.
• Process Chemistry: Used in research and development for route scouting and scale-up of new chemical entities (NCEs).
• Protease Inhibitor Synthesis: Serves as a precursor in the manufacturing of specific protease inhibitors.
• Carbamate Chemistry: Utilized in reactions where a protected amine or alcohol functionality is required.
• Chiral Pool Synthesis: Provides a source of defined stereochemistry for asymmetric synthesis in medicinal chemistry.
• Custom Synthesis: Employed by CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.

Basic Information

Product Name	tert-Butyl (Cis)-6-(Hydroxymethyl)-Tetrahydro-2H-Pyran-3-Ylcarbamate
CAS No.	603130-24-1
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	(3S,6R)-6-(Hydroxymethyl)-N-(tert-butoxycarbonyl)-tetrahydro-2H-pyran-3-amine; (3S,6R)-tert-Butyl 6-(hydroxymethyl)tetrahydro-2H-pyran-3-ylcarbamate; cis-tert-Butyl 6-(hydroxymethyl)tetrahydro-2H-pyran-3-ylcarbamate; Boc-protected cis-6-(hydroxymethyl)tetrahydropyran-3-amine; (3S,6R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]tetrahydro-2H-pyran-6-methanol; 603130-24-1; tert-Butyl cis-6-(hydroxymethyl)tetrahydro-2H-pyran-3-ylcarbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl (Cis)-6-(Hydroxymethyl)-Tetrahydro-2H-Pyran-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for stereochemical purity and standard pharmacopeial methods for identity and purity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.