Description

(2S,5R)-5-[(tert-Butoxycarbonyl)Amino]Tetrahydro-2H-Pyran-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a protected amine group and a carboxylic acid functionality. This compound is a critical chiral building block for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutics, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly protease inhibitors and peptidomimetics.
• Peptide Synthesis: Serves as a protected amino acid component in solid-phase and solution-phase peptide synthesis to introduce specific stereochemistry.
• Chemical Biology Research: Used as a tool compound for studying enzyme-substrate interactions and designing enzyme inhibitors.
• API Development: Employed in the synthetic route development for complex Active Pharmaceutical Ingredients requiring high stereochemical purity.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in catalytic asymmetric transformations.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals and advanced materials where precise molecular architecture is required.

Basic Information

Product Name	(2S,5R)-5-[(tert-Butoxycarbonyl)Amino]Tetrahydro-2H-Pyran-2-Carboxylic Acid
CAS No.	603130-13-8
Molecular Formula	C11H19NO5
Molecular Weight	245.27 g/mol
Synonyms	Boc-5-amino-tetrahydro-2H-pyran-2-carboxylic acid; (2S,5R)-5-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-2-carboxylic acid; (2S,5R)-5-(Boc-amino)tetrahydropyran-2-carboxylic acid; 5-[(tert-Butoxycarbonyl)amino]tetrahydro-2H-pyran-2-carboxylic acid (2S,5R)-; Boc-Amino-THP-COOH; (2S,5R)-BocNH-THP-COOH; 603130-13-8; tert-Butyl (2S,5R)-2-(carboxy)tetrahydro-2H-pyran-5-ylcarbamate
EINECS	Contact for details

Quality Control

Our (2S,5R)-5-[(tert-Butoxycarbonyl)Amino]Tetrahydro-2H-Pyran-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.