Description

1-(Triphenylmethyl)-n-(Phenylmethylene)-L-Histidine Methyl Ester is a sophisticated, protected amino acid derivative designed for advanced synthetic chemistry. This compound is a critical chiral building block, offering a high degree of selectivity and purity for the synthesis of complex peptides and other biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, peptide-based drugs, and biochemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Chemistry Research: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce protected histidine residues, enabling the construction of specific peptide sequences.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or affinity probes used in biochemical assays and diagnostic research.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new chemical entities with potential therapeutic value.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists in universities and corporate R&D labs focusing on amino acid and peptide methodology.

Basic Information

Product Name	1-(Triphenylmethyl)-n-(Phenylmethylene)-L-Histidine Methyl Ester
CAS No.	69937-82-2
Molecular Formula	C31H29N3O2
Molecular Weight	475.59 g/mol
Synonyms	N-[(Phenylmethylene)amino]-1-trityl-L-histidine methyl ester; L-Histidine, N-[(phenylmethylene)amino]-1-(triphenylmethyl)-, methyl ester; Trt-His(CHO)-OMe; Fmoc-His(Trt)-OH related protected derivative; 1-Trityl-N-benzylidene-L-histidine methyl ester; Protected L-Histidine methyl ester; N-Benzylidene-1-trityl-L-histidine methyl ester
EINECS	Contact for details

Quality Control

Our production of 1-(Triphenylmethyl)-n-(Phenylmethylene)-L-Histidine Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.