Description

(R)-(-)-2-(p-Toluenesulfonate)-1,2-Propanol is a high-purity chiral building block and pharmaceutical intermediate, specifically the (R)-enantiomer of the tosylate derivative of propylene glycol. This compound matters for its role in the stereoselective synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals, where the precise control of chirality is critical for biological activity and regulatory approval. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing new drugs, chiral catalysts, and specialty polymers.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key starting material for the preparation of (R)-configured APIs, including β-blockers, antifungals, and antiviral agents.
• Asymmetric Catalyst Ligand Precursor: Used in the synthesis of chiral ligands for transition metal catalysis in enantioselective reactions.
• Agrochemical Intermediate: Employed in the production of chiral pesticides and herbicides where specific stereochemistry enhances efficacy and reduces environmental impact.
• Monomer for Specialty Polymers: Serves as a functional monomer for creating polymers with specific optical or mechanical properties.
• Reference Standard: Used in analytical laboratories as a high-purity standard for method development and quality control in chiral analysis.
• Academic and Process R&D: A valuable reagent for exploring new synthetic methodologies and scaling up chiral processes in research and development.

Basic Information

Product Name	(R)-(-)-2-(p-Toluenesulfonate)-1,2-Propanol
CAS No.	69891-44-7
Molecular Formula	C10H14O4S
Molecular Weight	230.28 g/mol
Synonyms	(R)-1,2-Propanediol 2-Tosylate; (R)-Propylene Glycol 2-Tosylate; (R)-(-)-2-Tosyloxy-1-propanol; (R)-2-Hydroxypropyl p-Toluenesulfonate; (R)-2-(4-Methylbenzenesulfonyloxy)-1-propanol; (R)-PGT; (R)-PG Tosylate; (2R)-2-[(4-Methylphenyl)sulfonyl]oxy-1-propanol
EINECS	Contact for details

Quality Control

Our (R)-(-)-2-(p-Toluenesulfonate)-1,2-Propanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.