Description

3,6-Bis(Trimethylsiloxy)-1,3,5(10),6-Estratetren-17-One o-Methyl Oxime is a high-purity, organosilicon-modified steroid derivative, specifically designed for advanced pharmaceutical and research applications. This compound serves as a critical protected intermediate in the synthesis of complex steroidal molecules, offering enhanced stability and specific reactivity for targeted chemical transformations. It is primarily utilized by research institutions and pharmaceutical manufacturers specializing in hormone-related therapies, novel drug discovery, and the development of high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of novel steroidal drugs and active pharmaceutical ingredients (APIs).
• Hormone Research: Used in academic and industrial laboratories for studying estrogen receptor interactions and developing hormone analogs.
• Fine Chemical Synthesis: Employed in the production of specialized, high-value steroidal compounds for research and diagnostic purposes.
• Process Chemistry: Serves as a strategic intermediate to improve yield and selectivity in complex synthetic routes within GMP environments.
• Reference Standard: Can be supplied as a certified reference material for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	3,6-Bis(Trimethylsiloxy)-1,3,5(10),6-Estratetren-17-One o-Methyl Oxime
CAS No.	69833-97-2
Molecular Formula	C25H41NO3Si2
Molecular Weight	459.78 g/mol
Synonyms	3,6-Bis(trimethylsilyloxy)estra-1,3,5(10),6-tetraen-17-one O-methyloxime; Estrone 3,6-bis(trimethylsilyl) ether O-methyloxime; 69833-97-2; 3,6-Bis-O-(trimethylsilyl)estrone methyloxime; Silated Estrone Methyloxime Derivative; Estrone-3,6-bis(trimethylsiloxy)-17-one O-methyloxime
EINECS	Contact for details

Quality Control

Every batch of 3,6-Bis(Trimethylsiloxy)-1,3,5(10),6-Estratetren-17-One o-Methyl Oxime is manufactured and controlled under a strict quality management system. We provide comprehensive analytical documentation to support your regulatory and R&D needs. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC, NMR, and IR are available for each lot. Our quality commitment ensures material suitable for use in research and as a pharmaceutical intermediate under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.