Description

3,15α-Bis(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One o-Methyl Oxime is a high-purity, organosilicon-protected steroid derivative, specifically a silylated estrone oxime. This compound is a critical advanced pharmaceutical intermediate used in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs). Its primary value lies in the selective protection of hydroxyl groups, enabling sophisticated multi-step synthetic routes with high yield and purity. This material is essential for R&D and production teams in the pharmaceutical, biotechnology, and fine chemical sectors developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of steroidal drugs and hormone analogs.
• Research & Development: Used in medicinal chemistry for the discovery and development of new steroid-based therapeutic compounds.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex steroid molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Fine Chemical Synthesis: Utilized in the preparation of specialized steroidal compounds for academic and industrial research.

Basic Information

Product Name	3,15α-Bis(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One o-Methyl Oxime
CAS No.	69833-47-2
Molecular Formula	C25H43NO3Si2
Molecular Weight	461.80 g/mol
Synonyms	Estrone 3,15-bis(trimethylsilyl) ether O-methyloxime; 17-Oximino-3,15-bis(trimethylsiloxy)estra-1,3,5(10)-triene; 3,15-Bis-O-(trimethylsilyl)estrone O-methyloxime; Estrone-3,15-bis(TMS) ether methyloxime; Estrone 3,15-bis(trimethylsilyl ether) O-methyloxime; 69833-47-2; 3,15α-Bis(trimethylsiloxy)estra-1,3,5(10)-trien-17-one O-methyloxime
EINECS	Contact for details

Quality Control

Our 3,15α-Bis(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One o-Methyl Oxime is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.