Description

1-Iodo-4-Acetylthiobenzene is a versatile organosulfur and organoiodine compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an acetylthio and an iodo substituent on an aromatic ring, makes it a valuable precursor for constructing complex molecules through cross-coupling and functional group transformation reactions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting sulfur-containing heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the iodine atom facilitates efficient coupling reactions.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis.
• Material Science Research: Employed in the creation of novel organic electronic materials and liquid crystals due to its polarizable structure.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Chemical Biology Probes: Useful for incorporating iodine labels or thioester functionalities into molecules for biochemical studies.

Basic Information

Product Name	1-Iodo-4-Acetylthiobenzene
CAS No.	69746-43-6
Molecular Formula	C8H7IOS
Molecular Weight	278.11 g/mol
Synonyms	4-(Acetylthio)iodobenzene; 4-Iodophenyl Thioacetate; p-Iodophenyl Thioacetate; 1-Acetylsulfanyl-4-iodobenzene; (4-Iodophenyl) Ethanethioate; Acetic Acid 4-Iodophenyl Thioester; CAS 69746-43-6
EINECS	Contact for details

Quality Control

Our 1-Iodo-4-Acetylthiobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.