Description

1-O,2-O,3-o-Tris(Trimethylsilyl)-D-Ribofuranose 5-Phosphoric Acid Bis(Trimethylsilyl) Ester is a highly functionalized, silyl-protected derivative of D-ribose-5-phosphate, a critical intermediate in nucleotide and nucleoside chemistry. This compound is specifically engineered to provide superior stability and solubility in organic solvents, facilitating complex synthetic transformations. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for the synthesis of modified oligonucleotides, nucleoside analogs, and antiviral/anticancer prodrugs.

Application

• Pharmaceutical Intermediate: A key protected precursor in the synthesis of nucleoside analogs and modified nucleotides for antiviral and anticancer therapies.
• Oligonucleotide Synthesis: Used in the preparation of phosphoramidite building blocks for solid-phase synthesis of DNA/RNA oligonucleotides and their analogs.
• Prodrug Development: Serves as a masked phosphate group in the design of membrane-permeable prodrugs of nucleoside monophosphates (e.g., ProTide technology).
• Biochemical Research: Employed as a stable, soluble substrate or intermediate in enzymatic studies and metabolic pathway investigations.
• Labeled Compound Synthesis: Facilitates the incorporation of isotopic labels (e.g., 13C, 15N) into ribose moieties for tracer studies and analytical standards.
• Carbohydrate Chemistry: Acts as a versatile, fully protected starting material for the stereoselective synthesis of complex glycomimetics and sugar-modified compounds.

Basic Information

Product Name	1-O,2-O,3-o-Tris(Trimethylsilyl)-D-Ribofuranose 5-Phosphoric Acid Bis(Trimethylsilyl) Ester
CAS No.	69744-64-5
Molecular Formula	C20H51O8PSi5
Molecular Weight	603.07 g/mol
Synonyms	D-Ribofuranose, 5-(bis(trimethylsilyl) phosphate), 1,2,3-tris-O-(trimethylsilyl)-; 1,2,3-Tri-O-trimethylsilyl-D-ribofuranose 5-(bis(trimethylsilyl) phosphate); D-Ribose-5-phosphate, pentakis(trimethylsilyl) ester; Pentakis(trimethylsilyl) D-ribofuranose 5-phosphate; TMS-protected D-ribose-5-phosphate; Fully silylated D-ribose-5-phosphate
EINECS	Contact for details

Quality Control

Our production of this high-value synthetic intermediate adheres to stringent quality protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation, to ensure chemical identity and consistency. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment. We support development under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach ambient temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (by 1H NMR or 31P NMR)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.