Description

3,16α,17β-Tris(Trimethylsiloxy)Androsta-3,5-Diene is a high-purity, organosilicon-protected steroid derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a stable, reactive platform for the controlled introduction of functional groups at specific positions on the steroidal backbone. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for synthesizing novel steroid-based drug candidates, hormone analogs, and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel steroidal drugs, including potential anti-inflammatory, hormonal, and anticancer agents.
• Fine Chemical Synthesis: Used in the research-scale production of complex, high-value steroid derivatives for biological testing and structure-activity relationship (SAR) studies.
• Academic & Industrial Research: Serves as a model compound or starting material in methodological development for selective steroid functionalization and protection/deprotection strategies.
• Bioconjugate Chemistry: Potential use in creating steroid-protein or steroid-small molecule conjugates for targeted drug delivery or diagnostic applications.
• Reference Standard: Can be utilized as an analytical standard or certified reference material (CRM) for quality control in steroid manufacturing.

Basic Information

Item	Detail
Product Name	3,16α,17β-Tris(Trimethylsiloxy)Androsta-3,5-Diene
CAS No.	69705-66-4
Molecular Formula	C30H56O3Si3
Molecular Weight	549.0 g/mol
Synonyms	Androsta-3,5-diene-3,16α,17β-triol, tris(trimethylsilyl) ether; 3,16α,17β-Tris-O-(trimethylsilyl)androsta-3,5-diene; Tris(trimethylsiloxy)androsta-3,5-diene; TMS-protected androstadienetriol; Steroid TMS ether intermediate; 3,5-Androstadiene-3,16α,17β-triyl tris(trimethylsilyl) ether; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of 3,16α,17β-Tris(Trimethylsiloxy)Androsta-3,5-Diene is manufactured under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.