Description

(5Z,7E,22E)-3β-[(Dichloromethyl)Dimethylsiloxy]-9,10-Secoergosta-5,7,22-Triene CAS NO 69688-09-1 is a chemically modified secosteroid derivative, specifically a silyl-protected analog of a vitamin D precursor. This compound is of significant value as a key synthetic intermediate in the production of advanced vitamin D analogs and other high-value steroidal pharmaceuticals. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics for conditions related to calcium metabolism, bone health, and cell differentiation.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced vitamin D3 analogs and related secosteroids.
• Research & Development: Used in academic and industrial labs for studying vitamin D receptor (VDR) activation pathways and structure-activity relationships (SAR).
• Process Chemistry: Serves as a protected intermediate in multi-step organic synthesis, enabling specific chemical transformations.
• Biochemical Research: Tool compound for investigating the biological effects of modified vitamin D metabolites on cell proliferation and differentiation.
• Fine Chemical Synthesis: Precursor for creating specialized steroidal libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	(5Z,7E,22E)-3β-[(Dichloromethyl)Dimethylsiloxy]-9,10-Secoergosta-5,7,22-Triene
CAS No.	69688-09-1
Molecular Formula	C31H50Cl2OSi
Molecular Weight	537.72 g/mol
Synonyms	3β-[(Dichloromethyl)dimethylsilyloxy]-9,10-secoergosta-5,7,22-triene; (5Z,7E,22E)-3β-[(Dichloromethyl)dimethylsiloxy]cholesta-5,7,22-triene; Vitamin D3 Silyl Ether Intermediate; Dichloromethyl-dimethylsilyl-protected Provitamin D3; 9,10-Secoergosta-5,7,22-trien-3-ol, 3-[(dichloromethyl)dimethylsilyl] ether, (3β,5Z,7E,22E)-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material that meets high-purity specifications suitable for research and pharmaceutical synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles by techniques such as HPLC, NMR, and IR are available upon request. Quality is managed in line with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled with care, avoiding strong acids and organic solvents that may compromise its integrity. Keep the container tightly sealed under an inert atmosphere such as argon or nitrogen for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.