Description

Toluene-4-Sulfonic Acid 2-{2-[2-(Tetrahydropyran-2-Yloxy)-Ethoxy]-Ethoxy}-Ethyl Ester is a specialized organic intermediate featuring a unique polyether chain terminated with a tetrahydropyranyl (THP) protecting group. This compound is valued for its role as a functionalized building block in sophisticated organic synthesis, where its structure allows for selective deprotection and further chemical modification. It is primarily sought after by research institutions and fine chemical manufacturers engaged in developing pharmaceuticals, advanced materials, and complex specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly where controlled solubility or selective reactivity is required.
• Polymer & Material Science: Used in the synthesis of functional monomers and polymers, contributing to the development of specialty coatings, adhesives, and advanced polymeric materials with tailored properties.
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex molecular architectures, leveraging the THP-protected hydroxyl group for strategic synthetic steps.
• Ligand & Catalyst Development: Acts as a starting material for creating novel ligands or catalyst systems used in asymmetric synthesis and other catalytic processes.
• Prodrug Synthesis: Utilized in the design and synthesis of prodrug molecules, where the ester linkage and protecting group play a role in controlling drug release profiles.

Basic Information

Product Name	Toluene-4-Sulfonic Acid 2-{2-[2-(Tetrahydropyran-2-Yloxy)-Ethoxy]-Ethoxy}-Ethyl Ester
CAS No.	69502-33-6
Molecular Formula	C20H32O8S
Molecular Weight	432.53 g/mol
Synonyms	2-[2-[2-(Tetrahydropyran-2-yloxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate; 2-(2-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)ethoxy)ethyl p-toluenesulfonate; THP-PEG3-OTs; p-Toluenesulfonic acid 2-[2-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy]ethyl ester; PEG3-THP tosylate; Ethanol, 2-[2-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy]-, 4-methylbenzenesulfonate
EINECS	Contact for details

Quality Control

Our Toluene-4-Sulfonic Acid 2-{2-[2-(Tetrahydropyran-2-Yloxy)-Ethoxy]-Ethoxy}-Ethyl Ester is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.