Description

5-Fluoro-2,3-Dihydro-1,4-Benzodioxine is a high-value fluorinated heterocyclic building block, essential for advanced organic synthesis and pharmaceutical research. Its unique benzodioxine scaffold functionalized with fluorine offers significant potential for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances bioactivity and environmental persistence.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its rigid, oxygenated structure.
• Chemical Biology Probe Development: Employed in medicinal chemistry to create molecular probes for studying enzyme function and receptor binding sites.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.

Basic Information

Product Name	5-Fluoro-2,3-Dihydro-1,4-Benzodioxine
CAS No.	69464-49-9
Molecular Formula	C8H7FO2
Molecular Weight	154.14 g/mol
Synonyms	5-Fluoro-1,4-benzodioxane; 5-Fluoro-2,3-dihydro-1,4-benzodioxin; 5-Fluorobenzodioxane; 5-Fluoro-1,4-benzodioxin, 2,3-dihydro-; 69464-49-9; 5-Fluoro-2,3-dihydrobenzo[b][1,4]dioxine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2,3-Dihydro-1,4-Benzodioxine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.